Basic Information
VIS ID
TVIS10010950
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
487
Orient
+
Integrated sequence
CGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTC| |CAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGA
Host Sequence
Chromosome
chrX
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
30757947/30739830 (Hg38)
End
30757947/30739830 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRAXC
Nearest miRNA
hsa-mir-23c/Upstream/1165472; hsa-let-7f-2/Downstream/1843826;
Nearest TSS
ENST00000429181/Upstream/15656; ENST00000428263/Downstream/94793;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/86078, chrX-CpG: 77/Downstream/148954
Nearby gene
GK(-8370) ; TAB3(+87612) ;
Upstream sequence
agggttagggttagggttagggtgagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttaggg
Downstream sequence
ggtggcacatgcctgtaatcccagctacttgggaggctgaggcaagataattgcttgaacccagggggcggaggttgcagtgagccaagattgcaccact
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate