Basic Information
VIS ID
TVIS10010956
Fusion event
HBV-BCYRN1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chrX
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
70541247/71321397 (Hg38)
End
70541247/71321397 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
BCYRN1
Nearest miRNA
hsa-let-7f-2/Upstream/1298474; hsa-mir-105-1/Downstream/2896980;
Nearest TSS
ENST00000429181/Upstream/17605; ENST00000483365/Downstream/44842;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/37284, chrX-CpG: 86/Downstream/44468
Upstream sequence
agtgagccgagatcgcgccactgcactccagcctgggcgacagagcgagactcggtctcaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaagaag
Downstream sequence
tgctctgtcacccaggctggagtgcagtggcacgatctcagctcactggaagctctgcctcccgggttcaagcaattctcctgcctcagcctccccagta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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