Basic Information
VIS ID
TVIS10010968
Fusion event
HBV-chrY integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1824
Orient
-
Integrated sequence
TTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAG
Host Sequence
Chromosome
chrY
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
7038894/7170853 (Hg38)
End
7038894/7170853 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-3690-2/Upstream/2564625; hsa-mir-12120/Downstream/6308324;
Nearest TSS
ENST00000430575/Upstream/260167; ENST00000413466/Downstream/530394;
Nearest CpG islands
None/Target, chrY-CpG: 62/Upstream/258866, chrY-CpG: 170/Downstream/102627
Nearby gene
TBL1Y(-79170) ; PRKY(+103119) ;
Upstream sequence
ttactatccattccataccattccatcccattccattccattccattccattccattccattccattgcactgcactccattccattACATTCTACTCTA
Downstream sequence
ttctagtttctcctataagaatgatttctagtataaatttcaggattctgttgccttctttaggcacctgggctcaccaatcagaaagatataatttttc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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