Basic Information
VIS ID
TVIS10010970
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2238
Orient
+
Integrated sequence
AGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGA| |GAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGA
Host Sequence
Chromosome
chr12
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
33260405/33107471 (Hg38)
End
33260405/33107471 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1244-3/Upstream/7233392; hsa-let-7i/Downstream/9216229;
Nearest TSS
ENST00000382841/Upstream/118708; ENST00000541178/Downstream/318689;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/210362, chr12-CpG: 128/Downstream/331357
Nearby gene
PKP2(-210625) ; SYT10(+267943) ;
Upstream sequence
ttttagagtttctggtttttctgctctgtttcttccccatatttgtggttttatctacttttggtctttgatgatggtgatgtacagatgggtttttggt
Downstream sequence
gtggatatcctttccgtttgttagttttccttgtaacagtcaggaccctcagctgcaggtctgttggactttgctagaggtccactccagaccctgtttg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate