Basic Information
VIS ID
TVIS10010976
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2827
Orient
+
Integrated sequence
TTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATAT| |TCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAAC
Host Sequence
Chromosome
chr4
Cytoband
q33
Reference genome
GRCh37/hg19
Start
171375349/170454198 (Hg38)
End
171375349/170454198 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/5067861; hsa-mir-1305/Downstream/731986;
Nearest TSS
ENST00000502981/Upstream/111109; ENST00000505329/Downstream/289520;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/363846, chr4-CpG: 117/Downstream/1358385
Nearby gene
AADAT(-363977) ; HSP90AA6P(+127272) ;
Upstream sequence
ttaggggttagggtcagggttagggttagggttagggttttagggttagggttggggttggggttagggttagggttagggttagggttagggttagggt
Downstream sequence
ataatggcctccagcttcatccatgttcctgcaaaggacatgatcttgttctttttttatggctgcatagtattccatggtgtatatgtaccacattttc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate