Basic Information
VIS ID
TVIS10010977
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2479
Orient
-
Integrated sequence
ACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGG| |AACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAA
Host Sequence
Chromosome
chr4
Cytoband
q33
Reference genome
GRCh37/hg19
Start
171375356/170454205 (Hg38)
End
171375356/170454205 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/5067868; hsa-mir-1305/Downstream/731979;
Nearest TSS
ENST00000502981/Upstream/111116; ENST00000505329/Downstream/289513;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/363853, chr4-CpG: 117/Downstream/1358378
Nearby gene
AADAT(-363984) ; HSP90AA6P(+127265) ;
Upstream sequence
TATGTGAATTCTTTCCAATTTTGAATTGGTGCAGCTTTTTAAATAATTTCTTTAATGGGAGAGATGTATATAACTTTCCTTCCACACACAACAAATAAAC
Downstream sequence
cctccagcttcatccatgttcctgcaaaggacatgatcttgttctttttttatggctgcatagtattccatggtgtatatgtaccacattttctttatcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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