Fusion event
HBV-TERT integration
Detection method
PCR and Sanger sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Region type
X protein|precore/core protein|
Integrated sequence
GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT
End
1295173/1295058 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-4635/Upstream/232084; hsa-mir-10397/Downstream/14252;
Nearest cancer related gene
Upstream sequence
TTTTATATAAAGATTTACTCAAATAAgtcttagcatgaggtttccaggaaggaggcagtgagataagaagagaaatgcaagtggttaattagggagatgc
Downstream sequence
GCGAGGAGAgggcggggccgcggaaaggaaggggaggggctgggagggcccggagggggctgggccggggacccgggaggggtcgggacggggcggggtc
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.