Basic Information
VIS ID
TVIS10010982
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2238
Orient
+
Integrated sequence
AGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGA| |GAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGA
Host Sequence
Chromosome
chr6
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
49244387/49276746 (Hg38)
End
49244387/49276746 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/4078976; hsa-mir-10524/Downstream/2867603;
Nearest TSS
ENST00000381078/Upstream/1208057; ENST00000335783/Downstream/186445;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1207852, chr6-CpG: 20/Downstream/186475
Nearby gene
PTCHD4(-1207962) ; MUT(+153686) ;
Upstream sequence
agagagaaagtagaatggtggctgtcaggaactgggggaggagcctgggttgttgttctatggaagagtgcagccatagaaaagaacaagatcatgtctt
Downstream sequence
caaaagctcatctgtatgtcaccatcataaaagacaaaaggtagataaaatcacaaagatggggaaaaaacagagcagaaaagctgaaaattctaaaaat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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