Basic Information
VIS ID
TVIS10010984
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1577
Orient
-
Integrated sequence
GGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGAC| |CGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTC
Host Sequence
Chromosome
chrX
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
83811534/84556526 (Hg38)
End
83811534/84556526 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/330698; hsa-mir-105-1/Downstream/1279254;
Nearest TSS
ENST00000429181/Upstream/54047; ENST00000373173/Downstream/447300;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/368010, chrX-CpG: 46/Downstream/377533
Nearby gene
HDX(-54047) ; UBE2DNL(+377623) ;
Upstream sequence
AATTTTTACTATATCACATTCAAGCAGGGCCTTTCCAGTGCTCCTCATTTGTTTGCCAAATGTTTTTAAAAAAATGAAGTATTTGCCAACTCTCATTAGG
Downstream sequence
tgtacgtcaccatcatcaaagatcaaaggtagataaaaccacaaagatggggaaaaaacagagcagaaaagctgaaaattctaaaaatcagagcacatct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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