Basic Information
VIS ID
TVIS10010985
Fusion event
HBV-BRINP3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2099
Orient
+
Integrated sequence
CCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAAT| |GACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAA
Host Sequence
Chromosome
chr1
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
190277221/190308091 (Hg38)
End
190277221/190308091 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1K
Target gene
BRINP3
Nearest miRNA
hsa-mir-101-1/Upstream/9869701; hsa-mir-1182/Downstream/2408237;
Nearest TSS
ENST00000473358/Upstream/43193; ENST00000436905/Downstream/166710;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/3627142, chr1-CpG: 56/Downstream/2500411
Upstream sequence
GCCTAACCCAGATGAACTTAAACTTCAGTTTGTATGACCTTTCTGTTTGATATGGTATAAACATATATCAAAGGAGTCAAGGTAATAGGGAACCTCTAAC
Downstream sequence
TCCTTCCACACCCTCACCTACACCTAAAACTGTGGCTTCGATAGTTTTCAATTCTATTTAAGGGCAACGTAGACATAATTTTGCTTTTGAGAAGACATAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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