Basic Information
VIS ID
TVIS10010989
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1826
Orient
-
Integrated sequence
AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA
Host Sequence
Chromosome
chr12
Cytoband
q15
Reference genome
GRCh37/hg19
Start
70543925/70150145 (Hg38)
End
70543925/70150145 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7i/Upstream/565322; hsa-mir-1178/Downstream/9269112;
Nearest TSS
ENST00000382841/Upstream/203064; ENST00000552324/Downstream/30193;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/410366, chr12-CpG: 102/Downstream/92692
Nearby gene
RAB3IP(-326941) ; CNOT2(+92849) ;
Upstream sequence
TGTTTGTATCCAAAATTTTAATTTTGCATCTTTATTTTCTAAATTAAGGCAGCTATTTATGAATAAGATAACATTTTAAAAATCATCAATGTTAAAATAT
Downstream sequence
GCTGAAACATTTTGCTTTATCATTCATACAGAGTAAATCTCTGTATAATAATTAAGCATTGtacagcaacagcagtactaagagagaaattcatagcAGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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