VISDB Viral Integration Site DataBase

VIS ID

TVIS10010992

Fusion event

HBV-THSD4 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

2469

Orient

+

Integrated sequence

TAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCA| |TAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGAC

Chromosome

chr15

Cytoband

q23

Reference genome

Start

End

71707138/71414799 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-1909-5p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-512-3p ; hsa-mir-6768-3p ; hsa-mir-4484 ; hsa-mir-548an ; hsa-mir-4665-5p ; hsa-mir-4472 ; hsa-mir-1275 ; hsa-mir-4447 ; hsa-mir-5010-5p ; hsa-mir-4525 ; hsa-mir-7111-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-625-5p ; hsa-mir-6825-5p ; hsa-mir-7160-5p ; hsa-mir-6853-5p ; hsa-mir-6087 ; hsa-mir-4649-3p ; hsa-mir-1827 ; hsa-mir-670-5p ; hsa-mir-6848-5p ; hsa-mir-6846-5p ; hsa-mir-4697-5p ; hsa-mir-4488 ; hsa-mir-1237-5p ; hsa-mir-6816-5p ; hsa-mir-3196 ; hsa-mir-3180-3p ; hsa-mir-3180 ; hsa-mir-6787-5p ; hsa-mir-663a ; hsa-mir-6882-3p ; hsa-mir-1908-5p ; hsa-mir-4749-5p ; hsa-mir-4706 ; hsa-mir-4312 ; hsa-mir-637 ; hsa-mir-6852-5p ; hsa-mir-6791-5p ; hsa-mir-4308 ; hsa-mir-4292 ; hsa-mir-4438 ; hsa-mir-3925-3p ; hsa-mir-4709-3p ; hsa-mir-665 ; hsa-mir-6863 ; hsa-mir-766-3p ; hsa-mir-873-5p

Nearest miRNA

hsa-mir-10393/Upstream/1335331; hsa-mir-11181/Downstream/1172418;

Nearest TSS

Nearest CpG islands

None/Target, chr15-CpG: 55/Upstream/199442, chr15-CpG: 18/Downstream/397052

Upstream sequence

GGACATGGGTATGGATTCTTACTAATTGATGAAAAACATTCAAACTTTACGGCAACACAGTTTGCAGATAATAATTGCTAAAAGCCTGAAACAGACATTT

Downstream sequence

TCCAGGATGTGAGTATATTAATAGGGTTCTGATGTTACTAGGACTACTGGATACTACTTTGCATTTGTTCTCTGCATTTGCCTGAAATTCCCTCATTGAA