Basic Information
VIS ID
TVIS10010994
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2192
Orient
-
Integrated sequence
AACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTT| |CAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCA
Host Sequence
Chromosome
chr6
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
115646177/115325013 (Hg38)
End
115646177/115325013 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/8540793; hsa-mir-1202/Downstream/3744034;
Nearest TSS
ENST00000381078/Upstream/789138; ENST00000417846/Downstream/309178;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/981318, chr6-CpG: 74/Downstream/775497
Nearby gene
HS3ST5(-1262136) ; FRK(+616516) ;
Nearest cancer related gene
FRK(TSG, +616516) ;
Upstream sequence
TAGCCTCTTGATAGGTTAATAAGATAATGATaatctcatcttgaattgtggctcccataatccccacatgtggttggaggacctggtaggaggtaatata
Downstream sequence
ATATTGGAAAAATTCTCTTCTAAGCAGAAGACCCAGCTTCAGTCACTTAAATACCCTTTAGCTTTTTGTCCTAAACTAAATCCTCACACCTAATTTATAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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