Basic Information
VIS ID
TVIS10010999
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1820
Orient
+
Integrated sequence
TTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTAT
Host Sequence
Chromosome
chr1
Cytoband
p36.13
Reference genome
GRCh37/hg19
Start
20310425/19983932 (Hg38)
End
20310425/19983932 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA1A
Nearest miRNA
hsa-mir-12136/Upstream/1086784; hsa-mir-101-1/Downstream/649747;
Nearest TSS
ENST00000473358/Upstream/3516; ENST00000498348/Downstream/44247;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/100963, chr1-CpG: 36/Downstream/201935
Nearby gene
PLA2G2A(-3493) ; PLA2G5(+86276) ;
Nearest cancer related gene
PLA2G2A(TSG, -3493) ;
Upstream sequence
agtttcttccttctggtgggttcgtggtctcactggctcaggagtgaagctgccgacctttgcggtgagtcttacatctcataaaagcagtgtagaccca
Downstream sequence
aagagggagctgcaccaagatttattgcaaagagcaaaagaacaaagcctccatgctctggaaggggaccagagccggttgccactcctggctccgcagc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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