VISDB Viral Integration Site DataBase

VIS ID

TVIS10011001

Fusion event

HBV-CACNB2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

1103

Orient

-

Integrated sequence

GGGTCTTTTGGGTTTTGCTGCCCCTTTTACACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCG| |CCAACTTACAAGGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGTTGCCCGGCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCA

Chromosome

chr10

Cytoband

p12.33

Reference genome

Start

End

18474633/18185704 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-26b-5p ; hsa-mir-16-5p ; hsa-mir-640 ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-378a-5p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-4680-5p ; hsa-mir-4635 ; hsa-mir-3653-5p ; hsa-mir-5193 ; hsa-mir-4667-3p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-6865-3p ; hsa-mir-4260 ; hsa-mir-5572 ; hsa-mir-450a-2-3p ; hsa-mir-6857-5p ; hsa-mir-6763-5p ; hsa-mir-3150a-3p ; hsa-mir-6810-5p ; hsa-mir-2110 ; hsa-mir-19b-2-5p ; hsa-mir-19b-1-5p ; hsa-mir-19a-5p ; hsa-mir-4450 ; hsa-mir-2052 ; hsa-mir-186-3p ; hsa-mir-8087 ; hsa-mir-7161-5p ; hsa-mir-548u ; hsa-mir-208a-3p ; hsa-mir-208b-3p

Nearest miRNA

hsa-mir-1265/Upstream/340511; hsa-mir-107/Downstream/2366266;

Nearest TSS

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/44413, chr10-CpG: 24/Downstream/465895

Upstream sequence

CTGAGGTCAATAGCTTGCATTTGGAAAACAGAAATGAAAATACATCTTTTACCTTGACAAAAGGTTGGCAACTGATGGCAGAGATGATCAGAAAGTAGAA

Downstream sequence

ATAGGGTGTGTGAGTGGGATTCCCATTTGCGTAGCTTTCTTTGCATACCCAGCACattcattcatttaataaatatttattctgtgcctaccatgtgcca