VISDB Viral Integration Site DataBase

VIS ID

TVIS10011013

Fusion event

HBV-CEP128 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1821

Orient

-

Integrated sequence

TGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAA| |CTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATA

Chromosome

chr14

Cytoband

q31.1

Reference genome

Start

End

81014676/80548332 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-193b-3p ; hsa-mir-375 ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-10a-5p ; hsa-mir-6755-3p ; hsa-mir-367-5p ; hsa-mir-1267 ; hsa-mir-4762-5p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa

Nearest miRNA

hsa-mir-1260a/Upstream/3282042; hsa-mir-1185-1/Downstream/13399894;

Nearest TSS

Nearest CpG islands

None/Target, chr14-CpG: 35/Upstream/686344, chr14-CpG: 29/Downstream/393034

Upstream sequence

tagattttctgactattaatcagatactattttttctcatatcactttccaTCATTTAAAACTATTCATATAATAATTTTCAGCTAAAGATTGAAGGTAA

Downstream sequence

TTTGTTAAAACTAGATGCACAAAATGAAAATTCTCCATATTAGTTTTTCATTAAAGACTTTAAAATGTGTATAAAATATACTATTCCCCCCACTATATAT