Basic Information
VIS ID
TVIS10011017
Fusion event
HBV-LINC02203 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1836
Orient
+
Integrated sequence
AGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGC| |CTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTA
Host Sequence
Chromosome
chr15
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
22333066/22045115 (Hg38)
End
22333066/22045115 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
LINC02203
Nearest miRNA
hsa-mir-3118-2/Upstream/93792; hsa-mir-10393/Downstream/180163;
Nearest TSS
ENST00000557528/Upstream/29854; ENST00000614722/Downstream/25126;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/155120, chr15-CpG: 215/Downstream/212219
Upstream sequence
CAAGCTGGCCTGCATGGACACCTATGTGGTAGAGGTGCTGATGATAGCCAACAGTGGTCTGCTCTCTCTTGTCTGCTTCTTGGTCTTACTATTCTCTTAT
Downstream sequence
GCTGTCATCCTGATCACCCTGAGAACACACTTCGGCCAGGGCCAGAACAAGTTCCTCTCTACCTGTGCTTCTCACCTGACAGTGGTCAGCCTGATCTTCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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