Basic Information
VIS ID
TVIS10011037
Fusion event
HBV-LOC110806263 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2977
Orient
+
Integrated sequence
CTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGA| |CGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACT
Host Sequence
Chromosome
chr5
Cytoband
p15.33
Reference genome
GRCh37/hg19
Start
1297377/1297262 (Hg38)
End
1297377/1297262 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC110806263
Nearest miRNA
hsa-mir-4635/Upstream/234288; hsa-mir-10397/Downstream/12048;
Nearest TSS
ENST00000502646/Upstream/2193; ENST00000605200/Downstream/24567;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/1407, chr5-CpG: 18/Downstream/37700
Nearby gene
TERT(-2215) ; MIR4457(+12048) ;
Upstream sequence
TTTCTAAGCTTCCTAccacagcactcaggagagtgactggcatgaagtaggtgctaaataattaCGAGTTTTTAAGTGCCCAGAGAAGATGTACTCAACA
Downstream sequence
GGGGGGGATAGGGAAGGGGCTCAATCCCAGTAGAGTAGGAGGGATGGACTTTAATTTCTACATGTTTCAGCACACACTGAGACATTGAGATTCAGGACAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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