Basic Information
VIS ID
TVIS10011039
Fusion event
HBV-LOC107986409 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3170
Orient
+
Integrated sequence
ACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAG| |GCCATGCAGTGG
Host Sequence
Chromosome
chr5
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
28755322/28755215 (Hg38)
End
28755322/28755215 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5E
Target gene
LOC107986409
Nearest miRNA
hsa-mir-10397/Upstream/11599223; hsa-mir-103a-1/Downstream/3180887;
Nearest TSS
ENST00000502646/Upstream/467550; ENST00000602801/Downstream/54034;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/2085420, chr5-CpG: 76/Downstream/54078
Nearby gene
PURPL(-1258814) ; LSP1P3(+171655) ;
Upstream sequence
CTTTTAAATTATTCCTTTTTATCTTCAATTGTTTATACAGGTTTAACGGCAACAATCTTAACTAACAACAAGTAATGCCCTGGCTATTTATTGTACCATC
Downstream sequence
gttctagatccttgaggaatcgccacactgacttccacaatggttgaacagaacagaacagaacaaaaTAACAATGTTTTAAAGAAAGTTGAGgtcttag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate