Basic Information
VIS ID
TVIS10011044
Fusion event
HBV-LOC105374976 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1752
Orient
-
Integrated sequence
TACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGA| |GATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTT
Host Sequence
Chromosome
chr6
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
23484988/23484760 (Hg38)
End
23484988/23484760 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105374976
Nearest miRNA
hsa-mir-3691/Upstream/4912880; hsa-mir-10398/Downstream/3662866;
Nearest TSS
ENST00000381078/Upstream/147049; ENST00000475830/Downstream/641362;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/914284, chr6-CpG: 23/Downstream/641321
Nearby gene
HDGFL1(-914238) ; NRSN1(+641426) ;
Upstream sequence
TTTTAACCAGTCTGGGGATTTGCTTGCCTGGTGAGTCTCATATGCCATATTATGAATATGAAAATAATGAAGTTAATTTCCTGTTGCCTTTCTGTGTCAG
Downstream sequence
GCCTTTTATTTTCCAGATGAGCAAACTGAAGTATCTTCGTCCAGTAGTTAGAATTGTATAGTAAATGTATGAGCCCTTTTGCAAAGACATAAAAGATATA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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