Basic Information
VIS ID
TVIS10011058
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2182
Orient
+
Integrated sequence
TGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGG| |GCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCG
Host Sequence
Chromosome
chr1
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
121485311/121743513 (Hg38)
End
121485311/121743513 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/4648785; hsa-mir-1182/Downstream/24107074;
Nearest TSS
ENST00000473358/Upstream/162989; ENST00000443018/Downstream/21756999;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/223786, chr1-CpG: 312/Downstream/3341996
Nearby gene
EMBP1(-171625) ;
Upstream sequence
aggtcaatggtagaaaaggaaatatcttcgtatagaaacaagacagaatgattctcagaaactcctttgtgatgtgtgcgttcaactcacagagtttaac
Downstream sequence
ctttcttttcatagagcagttaggaaacactctgtttgtaaagtctgcaagtggatattcagacctccttgaggccttcgttggaaacgggatttcttca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate