UAP1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10011060
Fusion event
HBV-UAP1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2469
Orient
+
Integrated sequence
TAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCA| |TAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGAC
Host Sequence
Chromosome
chr1
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
162551924/162582134 (Hg38)
End
162551924/162582134 (Hg38)
Orient
-
Location type
Intronic
Target gene
UAP1
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-155-5p
Nearest miRNA
hsa-mir-101-1/Upstream/239494; hsa-mir-1182/Downstream/3325787;
Nearest TSS
ENST00000473358/Upstream/703; ENST00000486089/Downstream/15107;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/20071, chr1-CpG: 44/Downstream/208326
Upstream sequence
ttaGTTGTATAGGTGATGGCATGTCTTTATGGTAGCAAAAAATATATATATTATAGCTAGAAATAAAATAGACAGCAAACATGCAAACCTTTAAAAACAC
Downstream sequence
TTTGGAAGACCTAAAAATACTGATATAAACATTACTAGAAGTCtgtataggtatccattctcatcaaaaacagtgtaataaaagcccagtcaaaatctca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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