Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10011062
Fusion event
HBV-TIPRL integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|
Start
1754
Orient
-
Integrated sequence
CATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGA| |TTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCA
Host Sequence
Chromosome
chr1
Cytoband
q24.2
Reference genome
End
168152993/168183755 (Hg38)
Orient
+
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-29c-3p ; hsa-mir-26b-5p ; hsa-mir-587 ; hsa-mir-921 ; hsa-mir-3174 ; hsa-mir-744-3p ; hsa-mir-3928-5p ; hsa-mir-6806-3p ; hsa-mir-496 ; hsa-mir-8485 ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-574-5p ; hsa-mir-6867-5p ; hsa-mir-4711-3p ; hsa-mir-934 ; hsa-mir-3618 ; hsa-mir-627-3p ; hsa-mir-138-1-3p ; hsa-mir-5003-3p ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-5003-5p ; hsa-mir-4789-5p ; hsa-mir-4742-3p ; hsa-mir-654-3p ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-676-3p ; hsa-mir-6888-3p
Nearest miRNA
hsa-mir-101-1/Upstream/185029; hsa-mir-1182/Downstream/191769;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/4356, chr1-CpG: 87/Downstream/41952
Upstream sequence
AATAAGCTATTATATTACGTATTTGTATATTTATCTTATTTAGCCCACTACTTAGTACAGTGCCATATGATGATGAAAGAATGGATGATGAAAGCATTTT
Downstream sequence
ATAGACCTTGCAAATATATCATATTGATTAAATCATGTGCTGTGTAACTCATTCAGCAAGTAGGAAGAATTCTGTTGGGATGGAAAAGAAACAAAAATGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.