Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10011063
Fusion event
HBV-TIPRL integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
Polymerase|
Start
2776
Orient
+
Integrated sequence
ACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATA| |TTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAAT
Host Sequence
Chromosome
chr1
Cytoband
q24.2
Reference genome
End
168154574/168185336 (Hg38)
Orient
-
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-29c-3p ; hsa-mir-26b-5p ; hsa-mir-587 ; hsa-mir-921 ; hsa-mir-3174 ; hsa-mir-744-3p ; hsa-mir-3928-5p ; hsa-mir-6806-3p ; hsa-mir-496 ; hsa-mir-8485 ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-574-5p ; hsa-mir-6867-5p ; hsa-mir-4711-3p ; hsa-mir-934 ; hsa-mir-3618 ; hsa-mir-627-3p ; hsa-mir-138-1-3p ; hsa-mir-5003-3p ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-5003-5p ; hsa-mir-4789-5p ; hsa-mir-4742-3p ; hsa-mir-654-3p ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-676-3p ; hsa-mir-6888-3p
Nearest miRNA
hsa-mir-101-1/Upstream/186610; hsa-mir-1182/Downstream/190188;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/5937, chr1-CpG: 87/Downstream/40371
Upstream sequence
ATATATGAGCAAAAAgaacttctggttagacaaagtaggtttatgccctgtctgccctgagtatgaacctgaaatgactttaggaagttacttaatttga
Downstream sequence
gtctcagttttatcaataaattgggtaaacagaaatatctacctcaaagcagagttttgatgtgaaataatttatgggaagctctcaataaattctaaag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.