Basic Information
VIS ID
TVIS10011070
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1786
Orient
-
Integrated sequence
AACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGT| |AGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCT
Host Sequence
Chromosome
chr1
Cytoband
q41
Reference genome
GRCh37/hg19
Start
215716283/215542940 (Hg38)
End
215716283/215542940 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/3465255; hsa-mir-1182/Downstream/4574913;
Nearest TSS
ENST00000473358/Upstream/148522; ENST00000448333/Downstream/24452;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/459647, chr1-CpG: 76/Downstream/24224
Nearby gene
KCNK2(-305847) ; KCTD3(+24452) ;
Upstream sequence
gaaggcatgaaaagccctatgaagagagaaggtgacccatatacagtttcacttatggtagagcaggaaaggataaggtggttgttctaagagacacctt
Downstream sequence
aaagcaaggaaaaagaaagaaattgaaatgtttaaaaactcttaaaggctgagtgtaggcaaatgtgataatttacagttactaggagctccagaaataa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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