Basic Information
VIS ID
TVIS10011071
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2238
Orient
+
Integrated sequence
AGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGA| |GAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGA
Host Sequence
Chromosome
chr1
Cytoband
q44
Reference genome
GRCh37/hg19
Start
248507092/248343790 (Hg38)
End
248507092/248343790 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1I
Nearest miRNA
hsa-mir-101-1/Upstream/1141730; hsa-mir-3124/Downstream/482587;
Nearest TSS
ENST00000473358/Upstream/19222; ENST00000317861/Downstream/4985;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/406366, chr1-CpG: 49/Downstream/347939
Nearby gene
OR2M7(-19222) ; OR14C36(+4985) ;
Upstream sequence
GAAGTCTTTACATGAAGAAACACTGATGTTTCTGTCAGTCCTTTGAAAAATTGGTTGATCTACATTTGATCACTTTATATGACAAAAGCTGTTGTTAAAT
Downstream sequence
GACGTGATCCTATATCTAGTATATGAACATAGTGAGTATTCTTATTATTTATTAATATTATGATCATCATGCCTTTTCTTGACTCTAttttttttttctt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate