Basic Information
VIS ID
TVIS10011072
Fusion event
HBV-LOC101928391 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2633
Orient
+
Integrated sequence
ACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAATGAGAAAAGAAGATTGCAAT| |TGATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTT
Host Sequence
Chromosome
chr1
Cytoband
p36.11
Reference genome
GRCh37/hg19
Start
27384845/27058354 (Hg38)
End
27384845/27058354 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
LOC101928391
Nearest miRNA
hsa-mir-12136/Upstream/503761; hsa-mir-101-1/Downstream/3680802;
Nearest TSS
ENST00000473358/Upstream/45518; ENST00000472249/Downstream/41328;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/45404, chr1-CpG: 39/Downstream/96500
Nearby gene
TENT5B(-45512) ; SLC9A1(+40455) ;
Upstream sequence
CTTCCCAAACCAGGCTGCCAAGCCAAACCCAGTAAGGGCCTTTTAAGAACAAAAGGGCCTTTTAGTTAATGCAGCAGGATCTACTTTCCTTAGAAGGAAG
Downstream sequence
CTTTGGTTATAAATAACAACCTTTCCCCTCTGGATTCCTCCAGGTGCATTGGAAATTCAAATTTCAGAATAAGCTGACTGCCAAGAGGGCCCTCCCCCTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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