Basic Information
VIS ID
TVIS10011073
Fusion event
HBV-LOC101928391 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1758
Orient
-
Integrated sequence
AGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAG| |GTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTC
Host Sequence
Chromosome
chr1
Cytoband
p36.11
Reference genome
GRCh37/hg19
Start
27384872/27058381 (Hg38)
End
27384872/27058381 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
LOC101928391
Nearest miRNA
hsa-mir-12136/Upstream/503788; hsa-mir-101-1/Downstream/3680775;
Nearest TSS
ENST00000473358/Upstream/45545; ENST00000472249/Downstream/41301;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/45431, chr1-CpG: 39/Downstream/96473
Nearby gene
TENT5B(-45539) ; SLC9A1(+40428) ;
Upstream sequence
CCCAGTAAGGGCCTTTTAAGAACAAAAGGGCCTTTTAGTTAATGCAGCAGGATCTACTTTCCTTAGAAGGAAGCTTTGGTTATAAATAACAACCTTTCCC
Downstream sequence
CTCTGGATTCCTCCAGGTGCATTGGAAATTCAAATTTCAGAATAAGCTGACTGCCAAGAGGGCCCTCCCCCTGTCGGGAGTCCCTTAGTCCATGGGAAAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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