Basic Information
VIS ID
TVIS10011074
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3094
Orient
+
Integrated sequence
CTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCC| |TCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGCCATGCAGTGG
Host Sequence
Chromosome
chr10
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
46098504/45603056 (Hg38)
End
46098504/45603056 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA10G
Nearest miRNA
hsa-mir-1265/Upstream/438968; hsa-mir-107/Downstream/3382456;
Nearest TSS
ENST00000439456/Upstream/8150; ENST00000485850/Downstream/17871;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/8042, chr10-CpG: 78/Downstream/69173
Nearby gene
ZFAND4(+12535) ;
Nearest cancer related gene
ZFAND4(OG, +12535) ;
Upstream sequence
acaaggagaagatggccatctgcaaggcaaggaggtgtcagaagagctggtttctgaccaaaaatgtgagaaaattaatttgtccctgaagccgctcagt
Downstream sequence
ctgtgatactttgttatggcagccctacaaatgaatgcaGAATCCTAACACCATCTGGCAtatttgttttatttcctctagaatataaatgtgtgatgaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate