VISDB Viral Integration Site DataBase

VIS ID

TVIS10011076

Fusion event

HBV-SLIT1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

168

Orient

+

Integrated sequence

CTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATC| |ACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTT

Chromosome

chr10

Cytoband

q24.1

Reference genome

Start

End

98878635/97118878 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

FRA10D ; FRA10A ; FRA10B

Target gene

miRNAs that regulate target gene

hsa-mir-421 ; hsa-mir-4266 ; hsa-mir-6769a-5p ; hsa-mir-6769b-5p ; hsa-mir-92a-2-5p ; hsa-mir-654-5p ; hsa-mir-6508-3p ; hsa-mir-541-3p ; hsa-mir-4726-5p ; hsa-mir-4640-5p ; hsa-mir-5787 ; hsa-mir-4505 ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-7157-3p ; hsa-mir-6737-3p ; hsa-mir-5008-3p ; hsa-mir-4779 ; hsa-mir-4695-5p ; hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-570-3p ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-141-5p ; hsa-mir-1324 ; hsa-mir-629-3p ; hsa-mir-4713-5p ; hsa-mir-1197 ; hsa-mir-1224-5p ; hsa-mir-3064-3p ; hsa-mir-4722-3p ; hsa-mir-4751 ; hsa-mir-5004-5p ; hsa-mir-6727-3p

Nearest miRNA

hsa-mir-107/Upstream/290114; hsa-mir-1287/Downstream/756935;

Nearest TSS

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/75201, chr10-CpG: 108/Downstream/66427

Upstream sequence

agaaaaaatggggataaaagaatcctctcttataggattgctgtggggattaaatgagacagtacatataaaatgttagccatgacgactgggatatagt

Downstream sequence

aagtgcccaataaattatagctAAAAAACAAAAGGCATACACACACATGCACAACATATGGCTTGGAGAGAAACGGAAATACATCCCTGCTCTGACATGT