Basic Information
VIS ID
TVIS10011080
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
633
Orient
-
Integrated sequence
TACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGA| |AAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTT
Host Sequence
Chromosome
chr11
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
27856759/27835212 (Hg38)
End
27856759/27835212 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-210/Upstream/320165; hsa-let-7a-2/Downstream/221603;
Nearest TSS
ENST00000527297/Upstream/113154; ENST00000403099/Downstream/184363;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/112195, chr11-CpG: 25/Downstream/275104
Nearby gene
BDNF(-113154) ; KIF18A(+185404) ;
Upstream sequence
TGCCCTCCTTCAGCTAGGAGCAACGCACCTTGGTTTTCACAGTCTAATTGAAAAGAAAACGATTTCACATTTAAAAAATGAAATAACATGAAGTAACAGT
Downstream sequence
AAAATCCCTCATCATAGTTTATTTATTCATGTAACATTTAATTAATTAATTAAtttatttatttattttttatggagtctcctctgtcacccaggttgga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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