Basic Information
VIS ID
TVIS10011083
Fusion event
HBV-LOC440040 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
581
Orient
-
Integrated sequence
TAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACC| |TTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTA
Host Sequence
Chromosome
chr11
Cytoband
p11.12
Reference genome
GRCh37/hg19
Start
49802533/49780981 (Hg38)
End
49802533/49780981 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
LOC440040
Nearest miRNA
hsa-mir-129-2/Upstream/1684123; hsa-let-7a-2/Downstream/6962892;
Nearest TSS
ENST00000527297/Upstream/572311; ENST00000555099/Downstream/171410;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/222254, chr11-CpG: 25/Downstream/36747
Upstream sequence
attttccaggtgcgtctgtcaccccttcctttgactcggaaagggaactccctgaccccttgtgcttcccaggtgaggcaatgcctcgccctgcttcggc
Downstream sequence
tcgcgcagggtgcgcgcacccactggcctgcgcccactggcactccctagtgagatgaacccgaacccggtacctcagatggaaatgcagaaatcacccg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate