Basic Information
VIS ID
TVIS10011084
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1829
Orient
+
Integrated sequence
GACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCA| |CCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTT
Host Sequence
Chromosome
chr11
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
98307030/98436301 (Hg38)
End
98307030/98436301 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10392/Upstream/2094775; hsa-let-7a-2/Downstream/3083519;
Nearest TSS
ENST00000527297/Upstream/493539; ENST00000532109/Downstream/240090;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/2045878, chr11-CpG: 34/Downstream/584512
Nearby gene
CNTN5(+584676) ;
Upstream sequence
aaggacatgaacagacacttctcaaaagaagacatttatgcagccaaaaaacacatgaaaaaatgctcatcatcactggccatcagagaaatgcaaatca
Downstream sequence
aaaccactatgagataccatctcacaccagttagaatggcaatcattaaaaagtcaggaaagaacaggtgctgaagaggatgtggagaaataggaacact
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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