Basic Information
VIS ID
TVIS10011088
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1818
Orient
-
Integrated sequence
GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT
Host Sequence
Chromosome
chr12
Cytoband
q13.12
Reference genome
GRCh37/hg19
Start
51228972/50835189 (Hg38)
End
51228972/50835189 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA12A
Nearest miRNA
hsa-mir-1244-3/Upstream/600977; hsa-let-7i/Downstream/2063700;
Nearest TSS
ENST00000382841/Upstream/70680; ENST00000551456/Downstream/7731;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/70130, chr12-CpG: 27/Downstream/7661
Nearby gene
ATF1(-14029) ; TMPRSS12(+7729) ;
Nearest cancer related gene
ATF1(OG, -14029) ;
Upstream sequence
tttcactcaacacttctccttcctgctgccttgtgaagaaggtgctttgcttccccttccccttccaccataattgtaagtttcctgaggcttccccagc
Downstream sequence
catgctgaactgtgagtcaattaaatctctttcttttataaattacctagtctccagcagtgctttataacactgttttagtccatttatgaaaatggac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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