Basic Information
VIS ID
TVIS10011090
Fusion event
HBV-TEX30 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1805
Orient
-
Integrated sequence
TACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCG| |CACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATG
Host Sequence
Chromosome
chr13
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
103421070/102768720 (Hg38)
End
103421070/102768720 (Hg38)
Orient
-
Location type
Intronic
Target gene
TEX30
miRNAs that regulate target gene
hsa-mir-373-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-26b-5p
Nearest miRNA
hsa-mir-1297/Upstream/722716; hsa-mir-1267/Downstream/4762451;
Nearest TSS
ENST00000623511/Upstream/9650; ENST00000481069/Downstream/1550;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/171078, chr13-CpG: 154/Downstream/4228
Upstream sequence
AACTAATACCAAATTTGATAATGTTAACATCTAAAGTTCTAAAAAACTTATTAGTAAGCTTGAAATTATTTAGATcaggggtgttcaatcttttggtttc
Downstream sequence
tctgggccacagtggaagaactgtgttgtgccacacataaaatacactaacactcatgacacctgataagcttaaaaaaaaattgcaaaaaaaatctcat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate