Basic Information
VIS ID
TVIS10011091
Fusion event
HBV-chr13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1829
Orient
+
Integrated sequence
GACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCA| |CCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTT
Host Sequence
Chromosome
chr13
Cytoband
q14.11
Reference genome
GRCh37/hg19
Start
43352823/42778687 (Hg38)
End
43352823/42778687 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-2276/Upstream/1210292; hsa-mir-1267/Downstream/1417442;
Nearest TSS
ENST00000623511/Upstream/204383; ENST00000537894/Downstream/2863;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/506016, chr13-CpG: 38/Downstream/213251
Nearby gene
TNFSF11(-170674) ; FAM216B(+2863) ;
Upstream sequence
aggacatgaacagacacttctcaaaagaagacatttatgcagccaaaaaacacatgaaaaaatgctcatcatcactggccatcagagaaatgcaaatcTT
Downstream sequence
TTGATATCTTATCTCTTTCTTCTATAGATTTTATTTGAGATTATAGGGTTGAAACTAAATCTCTGGATATTCCCTTCTCAAGTCCACTTTAGActttttt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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