Basic Information
VIS ID
TVIS10011093
Fusion event
HBV-chr13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|precore/core protein|
Start
1823
Orient
-
Integrated sequence
TTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACT| |TTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAA
Host Sequence
Chromosome
chr13
Cytoband
q21.33
Reference genome
End
70204753/69630621 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
Nearest miRNA
hsa-mir-1297/Upstream/3412297; hsa-mir-1267/Downstream/8067391;
Nearby gene
LINC00550(-745296) ; KLHL1(+69972) ;
Upstream sequence
TCTCACAGTTGGTTTGTCACCAACTTTAGAATATGGCAGTAGGAGTGCTACGTTATAAGTATTTTGTTCAACTGTTTTAAATTATTTTAGTAGAAAGAAA
Downstream sequence
TCACTGCCTATAACAATTATTCTCCTTCTTGATTTTAAGATGTTCTTCTGGAAAACCTTATCCTACTGCTAGTGCATATCGCTCTTATTGCGGAAATCTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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