Basic Information
VIS ID
TVIS10011095
Fusion event
HBV-chr13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
535
Orient
-
Integrated sequence
TTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTA| |CTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAA
Host Sequence
Chromosome
chr13
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
93524359/92872106 (Hg38)
End
93524359/92872106 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1297/Upstream/381886; hsa-mir-1267/Downstream/3555123;
Nearest TSS
ENST00000623511/Upstream/5824; ENST00000443228/Downstream/184551;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/1472644, chr13-CpG: 139/Downstream/354886
Nearby gene
GPC5(-4872) ; GPC6(+354719) ;
Nearest cancer related gene
GPC5(TSG, -4872) ;
Upstream sequence
TACCAGTACAACCCAAGCGCGGTGGGAAGAACAAATATGAGTAAACAAGAAGTGTGTTGCTCAGTATCTCACCTAAGTTACCCCCAAGTGGTTATTtctg
Downstream sequence
agaggcaaaatcacttcattaaggtcacattgccagtgatagacaaagcaagcattctaaaatcagccttcaaaatccttttttccactgcaccacTCAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate