Basic Information
VIS ID
TVIS10011099
Fusion event
HBV-LINC01599 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1824
Orient
-
Integrated sequence
TTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAG
Host Sequence
Chromosome
chr14
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
50529687/50062969 (Hg38)
End
50529687/50062969 (Hg38)
Orient
+
Location type
Intronic
Target gene
LINC01599
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-208a/Upstream/96458; hsa-mir-1185-1/Downstream/236886;
Nearest TSS
ENST00000550708/Upstream/21740; ENST00000426751/Downstream/26206;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/59268, chr14-CpG: 60/Downstream/53283
Nearby gene
LINC01588(-55449) ; LINC01599(+20682) ;
Upstream sequence
AAAGTAACCTGTCAATTtagaaaaaacagattcaggcccagtgcagtggctcatgcctgtaatcccagcactgtgggaagctgatatgggcagattgctt
Downstream sequence
tgaactcaggagttcaagaccagcctgggcaacatggcaaaaccctacctctacaaaaaattagccaggcatcatggcacatgtctgtggtcccagctac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate