VISDB Viral Integration Site DataBase

VIS ID

TVIS10011102

Fusion event

HBV-SMOC1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1818

Orient

+

Integrated sequence

GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT

Chromosome

chr14

Cytoband

q24.2

Reference genome

Start

End

70496210/70029493 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-1260b ; hsa-mir-17-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-130a-3p ; hsa-mir-106b-5p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-20b-5p ; hsa-mir-519c-3p ; hsa-mir-526b-3p ; hsa-mir-519b-3p ; hsa-mir-519d-3p ; hsa-mir-519a-3p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-548t-5p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-548az-5p ; hsa-mir-6734-5p ; hsa-mir-1226-5p ; hsa-mir-6834-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-6875-5p ; hsa-mir-4419a ; hsa-mir-3126-5p ; hsa-mir-6822-5p ; hsa-mir-6750-5p ; hsa-mir-5582-3p ; hsa-mir-3689f ; hsa-mir-3689e ; hsa-mir-3689b-5p ; hsa-mir-3689a-5p ; hsa-mir-6735-3p ; hsa-mir-6811-3p ; hsa-mir-4679 ; hsa-mir-361-3p ; hsa-mir-6793-3p ; hsa-mir-4650-5p ; hsa-mir-1306-5p ; hsa-mir-500b-3p ; hsa-mir-495-3p ; hsa-mir-4477a ; hsa-mir-548n ; hsa-mir-4439 ; hsa-mir-3136-5p ; hsa-mir-3118 ; hsa-mir-134-5p ; hsa-mir-6857-3p ; hsa-mir-6855-3p ; hsa-mir-4513 ; hsa-mir-6730-3p ; hsa-mir-4761-5p ; hsa-mir-888-3p ; hsa-mir-624-3p ; hsa-mir-5584-3p ; hsa-mir-4446-5p ; hsa-mir-6875-3p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-623 ; hsa-mir-3156-3p ; hsa-mir-188-3p ; hsa-mir-6830-3p ; hsa-mir-3124-3p ; hsa-mir-6832-3p ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-1264 ; hsa-mir-6507-3p ; hsa-mir-204-5p ; hsa-mir-211-5p

Nearest miRNA

hsa-mir-208a/Upstream/2587563; hsa-mir-1185-1/Downstream/2487327;

Nearest TSS

Nearest CpG islands

None/Target, chr14-CpG: 35/Upstream/149683, chr14-CpG: 16/Downstream/16582

Upstream sequence

AGCCCTTCTTAGTGGATAGCTGAGGGATTGCAAAGAGGTGCCCAGCAGGAGCCAGGCCTTATGGAAAAGGGACTTTGTGTGAAGGCGTTGGCCAGTAATA

Downstream sequence

AGTTCACCTGAGCCATAGACACTCACAGAGCAAAAAGTAGGGCCAAACAACTTTTTGCTCTTTCCCAAGTCTGCTCTTTATTCTGAGGGTCAGAGAGGAC