Basic Information
VIS ID
TVIS10011104
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2235
Orient
+
Integrated sequence
TCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGA| |AGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGG
Host Sequence
Chromosome
chr18
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
11411678/11411679 (Hg38)
End
11411678/11411679 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-3976/Upstream/652030; hsa-mir-1-2/Downstream/243206;
Nearest TSS
ENST00000575820/Upstream/20950; ENST00000591029/Downstream/42799;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/261742, chr18-CpG: 127/Downstream/277383
Nearby gene
PIEZO2(-262917) ; GNAL(+277336) ;
Upstream sequence
GCTTGGAACAAATCAGAAAGACGATCTCTGGAGCTGGATGGCTCTGCAGCTGAAGCTTTATACTCTTTGCAAATTTATTTTTTACTATTAAAGGAGAAAT
Downstream sequence
TTCCCCCCAATAAATTGCCCAATTCCTTTTGTGATCACTTATGCCATCTTTTGTTTTTAAGAAAATGAAAGCAATGTGCATAATTTAAAAATAAGTAATA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate