VISDB Viral Integration Site DataBase

VIS ID

TVIS10011113

Fusion event

HBV-EPHA4 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1794

Orient

-

Integrated sequence

ACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAA| |ATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGC

Chromosome

chr2

Cytoband

q36.1

Reference genome

Start

End

222376943/221512223 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-10a-5p ; hsa-mir-335-5p ; hsa-mir-130b-3p ; hsa-mir-132-3p ; hsa-mir-93-5p ; hsa-mir-21-5p ; hsa-mir-505-3p ; hsa-mir-361-5p ; hsa-mir-320a ; hsa-mir-10b-5p ; hsa-mir-92a-3p ; hsa-mir-22-5p ; hsa-mir-143-5p ; hsa-mir-548ax ; hsa-mir-548ao-5p ; hsa-mir-4277 ; hsa-mir-5584-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-106a-5p ; hsa-mir-526b-3p ; hsa-mir-106b-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-5011-3p ; hsa-mir-1255b-5p ; hsa-mir-1255a ; hsa-mir-6744-5p ; hsa-mir-202-3p ; hsa-mir-676-5p ; hsa-mir-4735-5p ; hsa-mir-4275 ; hsa-mir-490-5p ; hsa-mir-5583-5p ; hsa-mir-3129-3p ; hsa-mir-4796-3p ; hsa-mir-548ah-5p ; hsa-mir-7844-5p ; hsa-mir-3609 ; hsa-mir-4500 ; hsa-let-7b-5p ; hsa-let-7c-5p ; hsa-let-7i-5p ; hsa-let-7d-5p ; hsa-mir-4458 ; hsa-let-7f-5p ; hsa-let-7g-5p ; hsa-let-7a-5p ; hsa-let-7e-5p ; hsa-mir-98-5p ; hsa-mir-498 ; hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-3180-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-4436b-5p ; hsa-mir-3124-3p ; hsa-mir-6832-3p ; hsa-mir-4673 ; hsa-mir-4645-5p ; hsa-mir-605-5p ; hsa-mir-592 ; hsa-mir-597-5p ; hsa-mir-3937 ; hsa-mir-4733-3p ; hsa-mir-1911-3p

Nearest miRNA

hsa-mir-10b/Upstream/1605658; hsa-mir-1244-1/Downstream/3498238;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/1884158, chr2-CpG: 260/Downstream/58787

Upstream sequence

TGAATGACTCTATAATAATATTTTTAAGTCACAAAAGCCAAGTAAACTTGTTTGCCTAATATGCTGAAGTTTATATTAGGAATAGAAACAAATGGATGCT

Downstream sequence

AAAAATTAAAATGACCACCATGTAAGAAAAAATCAAGAAAAGCGTATATTTTAGATGAACTAAATGTAGAAAGTAAGTAATCATATTTTGTAAGAAAACC