VISDB Viral Integration Site DataBase

VIS ID

TVIS10011115

Fusion event

HBV-SPTBN1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|

Start

2879

Orient

+

Integrated sequence

TATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCT| |CTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACG

Chromosome

chr2

Cytoband

p16.2

Reference genome

Start

End

54804929/54577792 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

FRA2S ; FRA2D ; FRA2H

Target gene

miRNAs that regulate target gene

hsa-mir-9-5p ; hsa-mir-215-5p ; hsa-mir-34a-5p ; hsa-mir-192-5p ; hsa-mir-93-5p ; hsa-mir-1301-3p ; hsa-mir-615-3p ; hsa-mir-589-3p ; hsa-mir-193b-3p ; hsa-mir-423-3p ; hsa-mir-331-3p ; hsa-mir-195-5p ; hsa-mir-26a-5p ; hsa-let-7e-5p ; hsa-let-7a-5p ; hsa-mir-145-5p

Nearest miRNA

hsa-mir-1301/Upstream/728587; hsa-mir-10b/Downstream/1405175;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/18960, chr2-CpG: 30/Downstream/51169

Nearest cancer related gene

SPTBN1(TSG, No orient, 0)

Upstream sequence

gctgtgcccaaggacacttaactagtaaatggagccaggattccaacccacgcagtgcgctttgggactcaatttttaaccatcttgctgtgctgCCTGT

Downstream sequence

TGAGCATTTTTCACCTGGTGCTTTTGTAGATCCCACATTAGGATTTTGTTAGGACCCTGGGCAACCTTGATTTAGTGAAAGCAGTTGTTGAGAGGTAGAA