CRYAA _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10011118
Fusion event
HBV-CRYAA integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1806
Orient
-
Integrated sequence
ACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGC| |ACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGG
Host Sequence
Chromosome
chr21
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
44590537/43170427 (Hg38)
End
44590537/43170427 (Hg38)
Orient
+
Location type
Intronic
Target gene
CRYAA
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-26b-5p
Nearest miRNA
hsa-let-7c/Upstream/219413; hsa-mir-6070/Downstream/439460;
Nearest TSS
ENST00000624081/Upstream/200; ENST00000435702/Downstream/161612;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/16464, chr21-CpG: 19/Downstream/75
Upstream sequence
GGTCATGCCTGTCTGTCCAGGAGACAGTCACAGGCCCCCGAAAGCTCTGCCCCACTTGGTGTGTGGGAGAAGAGGCCGGCAGGTGACCGAAGCATCTCTG
Downstream sequence
TTCTGATAACCGGGACCCGCCCTGTCTCTGCCAACCCCAGCAGGGACGGCACCCTCTGGGCAGCTCCACATGGCACGTTTGGATTTCAGGTTCGATCCGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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