VISDB Viral Integration Site DataBase

VIS ID

TVIS10011119

Fusion event

HBV-TRIM25 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2291

Orient

+

Integrated sequence

TCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCC| |AGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCT

Chromosome

chr21

Cytoband

p11.2

Reference genome

Start

End

9827110/8988277 (Hg38)

Orient

-

Location type

downstream

Target gene

miRNAs that regulate target gene

hsa-mir-124-3p ; hsa-mir-877-3p ; hsa-mir-526b-5p ; hsa-mir-1299 ; hsa-mir-193a-5p ; hsa-mir-3202 ; hsa-mir-3663-3p ; hsa-mir-4533 ; hsa-mir-6730-5p ; hsa-mir-6128 ; hsa-mir-875-3p ; hsa-mir-1182 ; hsa-mir-378a-5p ; hsa-mir-549a ; hsa-mir-4793-5p ; hsa-mir-7977 ; hsa-mir-521

Nearest miRNA

hsa-mir-10396a/Upstream/612; hsa-let-7c/Downstream/4418107;

Nearest TSS

Nearest CpG islands

None/Target, chr21-CpG: 261/Upstream/299, chr21-CpG: 20/Downstream/81901

Upstream sequence

gttgatcctgccagtagcatatgcttgtctcaaagattaagccatgcatgtctaagtacgcacggccggtacagtgaaactgcgaatggctcattaaatc

Downstream sequence

agttatggttcctttggtcgctcgctcctctcctacttggataactgtggtaattctagagctaatacatgccgacgggcgctgacccccttcgcggggg