Basic Information
VIS ID
TVIS10011124
Fusion event
HBV-LOC107986086 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
577
Orient
+
Integrated sequence
CCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCA| |AACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAG
Host Sequence
Chromosome
chr3
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
52317399/52283383 (Hg38)
End
52317399/52283383 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC107986086
Nearest miRNA
hsa-let-7g/Upstream/15022; hsa-mir-12124/Downstream/10836;
Nearest TSS
ENST00000440867/Upstream/4740; ENST00000473583/Downstream/3706;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/4342, chr3-CpG: 21/Downstream/4420
Nearby gene
WDR82(-4740) ; GLYCTK(+4437) ;
Upstream sequence
CGTATAGAGTAGTTTGCTGGCAAAAGATCAGGGTTCAGTGACAAGCCAGCCAGCTAGCTAAGAAAAATTACTACATACTTTAACTTTTAAGAACAGAATT
Downstream sequence
ctgagaggttaactttctcagggtcacttaaccaataagcactgaagtctggattcacactctgcttcagcactggaaagcttgtgttctgtttccaggg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate