KCNN2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10011129
Fusion event
HBV-KCNN2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1806
Orient
-
Integrated sequence
ACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGC| |ACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGG
Host Sequence
Chromosome
chr5
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
113605332/114269635 (Hg38)
End
113605332/114269635 (Hg38)
Orient
-
Location type
Intronic
Target gene
KCNN2
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-10397/Upstream/3755720; hsa-mir-103a-1/Downstream/1986108;
Nearest TSS
ENST00000502646/Upstream/213629; ENST00000505491/Downstream/91310;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/213327, chr5-CpG: 180/Downstream/91508
Nearby gene
YTHDC2(-674348) ; KCNN2(+92684) ;
Upstream sequence
aaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaacc
Downstream sequence
gttcattcaggagccccaggttCATCTATGAACTCCAGAGGTAGGATCCGGTTGACTGTAAGAATGTCTTTCCTTTCAATAAAAATGAAAATCTGCTCAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate