KCNN2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10011130
Fusion event
HBV-KCNN2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2346
Orient
+
Integrated sequence
TATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTT| |GTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTC
Host Sequence
Chromosome
chr5
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
113625263/114289566 (Hg38)
End
113625263/114289566 (Hg38)
Orient
+
Location type
Intronic
Target gene
KCNN2
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-10397/Upstream/3775651; hsa-mir-103a-1/Downstream/1966177;
Nearest TSS
ENST00000502646/Upstream/233560; ENST00000505491/Downstream/71379;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/233258, chr5-CpG: 180/Downstream/71577
Nearby gene
YTHDC2(-694279) ; KCNN2(+72753) ;
Upstream sequence
ctaaccctaaccctaatcctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaa
Downstream sequence
gggtttcaccatgttggccagggtggtctcaaactcctgacctcaagtgatctgcccgccttggcctttcaaagtgctgggattgcaggagtaagccacc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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