Basic Information
VIS ID
TVIS10011133
Fusion event
HBV-LOC101927421 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
635
Orient
+
Integrated sequence
CTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAA| |ATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCA
Host Sequence
Chromosome
chr5
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
124612606/125276913 (Hg38)
End
124612606/125276913 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC101927421
Nearest miRNA
hsa-mir-10397/Upstream/6122197; hsa-mir-103a-1/Downstream/3820775;
Nearest TSS
ENST00000502646/Upstream/240275; ENST00000625219/Downstream/48437;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/624858, chr5-CpG: 30/Downstream/1146442
Nearby gene
ZNF608(-531801) ; GRAMD2B(+1083182) ;
Upstream sequence
GCTTTTAAATTATTCCTTTTTATCTTCAATTGTTTATACAGGTTTAACGGCAACAATCTTAACTAACAACAAGTAATGCCCTGGCTATTTATTGTACCAT
Downstream sequence
GAAATCAGGGCTGTTAGGAAGAGGGCAAGGGATGGCTGTGAGGCAGCCAAAGCAGAATGTTCAGAGATGGGCATGCTCTTCTTTCTGGAAAAGTAAAGTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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