Basic Information
VIS ID
TVIS10011136
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1807
Orient
-
Integrated sequence
CTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCA| |CCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGA
Host Sequence
Chromosome
chr5
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
33315487/33315381 (Hg38)
End
33315487/33315381 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA5A
Nearest miRNA
hsa-mir-10397/Upstream/920906; hsa-mir-103a-1/Downstream/2832511;
Nearest TSS
ENST00000502646/Upstream/17471; ENST00000502508/Downstream/125238;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/601037, chr5-CpG: 55/Downstream/125148
Nearby gene
LINC02120(-352914) ; TARS(+125315) ;
Upstream sequence
ATAGTCTTTAATTCTGCCCTGTTTCCCACCATGTCCATCCTTTTCTATGCTAAGTCATAATGTTTCCACATAGAATCCTTTGAAATTTACTATCCTGTTT
Downstream sequence
CAAATAACTGGATAAAAGTACATAGTTAGATGATGCAGAATGTGTGTATGCCTGGACTAAACCAGGCCTCTAGCCAGATGATTAGCCACATCGAAAAATT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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